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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well cause an increase in methadone plasma concentrations, which could bring about possibly lethal respiratory despair. In addition, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may cause a rise in methado